The association between early-life relative telomere length and childhood neurodevelopment
نویسندگان
چکیده
منابع مشابه
Parental responsiveness moderates the association between early-life stress and reduced telomere length.
Early-life stress, such as maltreatment, institutionalization, and exposure to violence, is associated with accelerated telomere shortening. Telomere shortening may thus represent a biomarker of early adversity. Previous studies have suggested that responsive parenting may protect children from the negative biological and behavioral consequences of early adversity. This study examined the role ...
متن کاملTelomere length in early life predicts lifespan.
The attrition of telomeres, the ends of eukaryote chromosomes, is thought to play an important role in cell deterioration with advancing age. The observed variation in telomere length among individuals of the same age is therefore thought to be related to variation in potential longevity. Studies of this relationship are hampered by the time scale over which individuals need to be followed, par...
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OBJECTIVES Chronic exposure to psychosocial stressors is related to worse somatic health. This association applies both to stressors early in life, such as childhood adversities, and more recent life stress, such as stressful life events. This study examined whether accelerated telomere shortening, as an indicator of cellular aging, might be an explanatory mechanism. METHODS We examined wheth...
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BACKGROUND AND AIM: Early childhood caries (ECC) is a specific form of rampant dental caries affecting infants and young children. ECC is still a problem that threatens the health of the community and its management is important. It is believed that the majorities of children with ECC also suffer from malnutrition, anemia, low weight and altered physical growth patterns. This study was undertak...
متن کاملGenome-Wide Association Study of Relative Telomere Length
Telomere function is essential to maintaining the physical integrity of linear chromosomes and healthy human aging. The probability of forming proper telomere structures depends on the length of the telomeric DNA tract. We attempted to identify common genetic variants associated with log relative telomere length using genome-wide genotyping data on 3,554 individuals from the Nurses' Health Stud...
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ژورنال
عنوان ژورنال: NeuroToxicology
سال: 2018
ISSN: 0161-813X
DOI: 10.1016/j.neuro.2018.01.005